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In short, radical species can attack most
biological substrates from large macromolecules to smaller molecules
such as catechols. Exceptionally, stable radical species can be
formed, mostly due to steric protection of the unpaired electron.
Examples include the melanins (72-75)and the stable radical
derivatives produced in spin-trapping measurements.(7,28)
Cerovive is a registered trademark
of the astrazeneca company for the disulfate derivative of PBN or
phenylbutylnitrone. Go to the link above for more details.
Cerovive is currently in Phase-3 trials for stroke.
This compound is also called nxy-059. The Renovis company
is currently undergoing an ipo ( initial public offering ).
Recently, Renovis bought the intellectual property of Centaur
Pharmaceuticals. This includes nominal claims to cerovive.